The Moment Everything Changed

  • News so big it’ll take politics off the cable channels
  • An end to most major diseases? It’s closer than you might think
  • Factories humming: Key manufacturing number sets a 14-year high
  • Kavanaugh hearings underway, economic/investment issues at stake
  • Canned wine is a thing now (recommendations below)
  • Insider trading as a victimless crime… can stoned Americans compete in a global marketplace?… video games as a spectator sport… and more!

For years, a scientist we’ll call “Dr. Edward” has toiled in anonymity. But within weeks, maybe days, he’ll be the toast of the world.

“He’ll be on the front page of every newspaper in America,” says our science-and-wealth maven Ray Blanco.

(He might even knock politics off the cable news channels for a day or two. What’s happening is that big!)

“When we met years ago,” Ray recalls, “what he revealed to me in our one-on-one conversation left me convinced that this is the man who will change the world.

“He’ll go down as one of the greatest innovators in history,” Ray continues, “possibly as the man who eliminated disease from this planet.”

(Yup, that big.)

Tomorrow morning at 7:30 a.m. EDT, a group of scientists will make an announcement at a medical conference.

For the moment, this event is flying under the mainstream radar. The announcement will have to do with the treatment of a rare disease affecting — at most — one out of 100,000 people.

But it’s how this treatment works that’s so revolutionary: “Long term,” says Ray, “studies from both MIT and Harvard reveal that the medical breakthrough could cure up to 15,000 diseases.

“I’ve seen the technology behind it and my research into this topic spans years. This announcement could go down in the history books as one of the biggest moments of our lifetime.”

If you haven’t figured it out already, we’re talking about a means of science “editing” your DNA to eliminate mutations, and thus the possibility for disease. But it’s not what you might think.

When it comes to gene editing, it’s a technology called CRISPR that gets all the headlines. We first clued you into it nearly three years ago.

By last year, the state of the CRISPR art had advanced to a point where Ray told us it was plausible that pig organs could one day be transplanted into people. “Researchers have edited one gene sequence responsible for a retrovirus and raised pigs without them,” he said. “One day, they might be able to edit all genes responsible for tissue rejection.”

Breakthrough stuff, for sure. The problem, as Ray explained to his readers earlier this year, is that “CRISPR’s ability to target a particular location on the genome written in our DNA isn’t perfectly precise, meaning changes could be made off target. This has raised concerns about accidentally introducing mutations that could cause cancer.”

Thing is, CRISPR isn’t the only way to edit DNA within the nuclei of your cells.

What Ray’s talking about — what might set the world on its ear tomorrow — is unlike any other gene-editing technology.

“Other recently approved gene therapies don’t modify nuclear DNA when they are given to a patient,” he explains. “They simply add a little piece of additional DNA that codes for a desired protein. If the original treated cell divides, its daughter cells can lose protection.”

What good is that, really?

The technology Ray’s so excited about gets around that problem. “It’s not just the cell that gets the change, but also all cells descended from it, and that it’s done in a living human patient, not a line of cells in a test tube.”

Now are you getting the idea how this treatment for a rare disease has the potential to treat some of the most common ones? Even cancer and heart disease and Alzheimer’s?

And it all goes public tomorrow morning.

Yes, the investment potential is enormous. “Make no mistake,” says Ray, “the financial rewards at stake here are so exceptionally rare that it’s impossible to accurately predict just how high and fast share prices can soar for Dr. Edward’s company and others like it after the announcement is made.

“I believe this could hand you the kind of gains that could change the trajectory of your family and its fortune by getting in ahead of the announcement tomorrow.”

It all happens bright and early tomorrow — 7:30 a.m. EDT. If you want to get ahead of the announcement… and the headlines… and the profits… you’ll want to see Ray’s full write-up immediately at this link.

There’s no “boring, long-winded presentation” to watch — just the essential information you’ll need to decide whether this opportunity is for you. Click here to get started.

A new trading month is starting on a slightly down note for the U.S. stock market — all the major indexes are in the red, but by no more than a quarter percent. Amazon is bucking the trend, joining Apple in the trillion-dollar market cap club.

Bonds are selling off, the 10-year Treasury yield now 2.9%. Gold is selling off too, the bid sinking to $1,192. But with a tropical storm bearing down on the Gulf Coast, West Texas Intermediate prices have jumped back above $70.

The big economic number of the day delivered a huge upside surprise: The ISM manufacturing index clocks in at 61.3 — the highest level since May 2004. Everything within the index looks solid — even the “prices paid” component, which shows manufacturers’ input costs are easing a bit.

The latest battle in Washington over the Supreme Court entails “a list of legal and economic issues that will affect your portfolio,” says Jim Rickards.

Confirmation hearings begin today for nominee Brett Kavanaugh; if confirmed, he’d fill the spot left open by the retirement of Justice Anthony Kennedy.

Really, if they grew Supreme Court justices in a test tube, you’d end up with something a lot like Kavanaugh. He grew up in D.C., attended Georgetown Prep, attained a Yale law degree, clerked for none other than Justice Kennedy.

Expect much D.C. theater this month, as happens with any Supreme Court nomination, but Jim says the outcome is all but certain: Republicans have a 51-48 majority in the Senate… whoever fills out John McCain’s term will be a Republican and might be named this week… [Just in: It’ll be former Arizona Sen. Jon Kyl]… and at this stage there’s only one potential GOP holdout (Lisa Murkowski of Alaska). Kavanaugh will be in place for the start of the court’s new term Oct. 1.

Among the issues Jim says are at stake once Kavanaugh is in place for the start of the court’s new term Oct. 1…

  • An obscure case challenging the constitutionality of the Federal Housing Finance Agency. In theory it’s an executive branch agency, but the White House has little control over it. An appeals court has ruled the FHFA is unconstitutional. “If Kavanaugh joins a majority to uphold the decision,” says Jim, “the implications go far beyond FHFA and may trim the power of agencies from the Consumer Financial Protection Bureau to the SEC”
  • The “Russiagate” scandal hangs over markets… and Jim believes the high court will end up deciding one or several related cases. He reminds us Kavanaugh was a key player on independent counsel Kenneth Starr’s team that investigated Bill Clinton two decades ago
  • “Finally,” says Jim, “a long list of hot-button issues including immigration, voting rights, affirmative action, gun regulation, trade wars, climate control and environmental protection are the subject of current or prospective litigation. These issues will have a profound impact on the economy in relation to the size of the labor force, real wages, operating expenses and regulatory relief.”

And then there’s what Jim says is the biggest issue of all — the mountain of debt hanging over the government, corporations and households. “Eventually,” says Jim, “this will raise issues of default, inflation or renegotiation on unpayable debt… Kavanaugh’s temperament is to allow contracts to prevail and not to support government bailouts at every turn.

“This could result in much higher defaults and bond losses than investors now expect.”

How the canned wine business has grown in three years.

Late in 2015, we took note of a new Sonoma County brand called Mancan — marketed to men under the slogan “Shut up and Drink.”

Now the market-research firm Nielsen says canned wine is a $45 million business, and not for men only. Separate figures from another firm called BW 166 says sales grew 43% over the last year.

That said, canned wine accounts for a mere 0.2% of total wine sales… but the growth trajectory is likely to continue, thanks to millennial drinkers. “Millennials aren’t looking to spend $70 on a bottle of wine,” Food & Wine magazine’s Ray Isle tells CNBC.

A typical 375-milliliter can runs between $4–7 — which translates to between $8–14 a bottle.

Key point, says CNBC: “These cans can be brought to places that glasses cannot, like the beach, the park and campsites. Wine cans are also easier to recycle than glass bottles and are seen as less pretentious to casual drinkers.”


Meanwhile, in another sign canned wine has arrived, New York magazine’s Grub Street site has taste-tested nearly two dozen varieties.

We’ll spare you the drama: Dear Mom Oregon comes out best among the reds, Gotham Project Pinot Grigio among the whites, House Wine Rosé for rosé and Sofia Blanc de Blancs for sparkling wines.

The last of that bunch is deemed “best for drinking somewhere you shouldn’t” thanks to the red can and supplied straw.

A straw!? The horror!

“About insider trading,” a reader writes after we channeled Doug Casey last week and labeled it a victimless crime…

“I own 100 shares of ABC and someone gets insider info that they are being bought.

“Why am I even in the market if that’s the game?? Pretty soon, no game??”

The 5: Unless you decided to sell the shares between the time of that insider tip and the time of the announcement, what do you care? You’ll benefit from the resulting pop in the share price regardless.

If anything, you’re likely to profit more than the recipient of the insider info because you owned your shares a longer time and presumably bought them at a lower price.

“Is Doug Casey finally wrong?” chimes in a long-timer.

“I love his contrarian bent, but in this case I’m wondering if he has ‘jumped the shark’ to contend that insider trading is a victimless crime?

“I’ve said before in previous 5s that there is a commodity that is drying up rapidly in almost every country and market in the world.

“I’ll wait for your guesses…

“Trust in everything is disappearing: in governments, in currencies, in central banks, the FBI, the CIA, the Justice Department, the ‘news’…

“To suggest we need less trust, and that the final implications of that loss of trust will be victimless, well, I just don’t think I need to say anything further.”

The 5: Mr. Casey’s been hammering away at the theme of insider trading as a victimless crime for well over 20 years. He did an extended riff in his 1995 book Crisis Investing for the Rest of the ’90s.

To be sure, we’d say there are instances of “insider trading” where victims might be found. Take the Equifax hack last year. It turned out three top executives dumped $1.8 million in shares only days after the company discovered the breach on July 29 — and weeks before it was made public.

The company says the execs were not aware of the breach at that time, and they have not been charged with insider trading. But if they did know, that would be unconscionable and ought to be dealt with under the fraud statutes.

On the subject of cannabis consumption and civilizational decline, a veteran reader writes:

“One question: How do we compete with the world and preserve our standard of living if everyone is stoned?”

“Just got back from Germany — Berlin in particular is going places.”

“The foreigners are bringing it. How do we compete if everyone is stoned out of their minds?”

The 5: Really?

People are going to get stoned anyway. It’s just a matter of whether the government is going to squander precious resources on people inhaling a substance of which it does not approve.

By the way, possession of “a small amount” of marijuana has been legal in Germany since 1992. That amount varies from state to state, but in Berlin it’s up to 15 grams, or about half an ounce…

“You sound stodgy,” a reader writes after Greg Guenthner’s observations on video gaming Friday.

Specifically, he was struck that Greg was agog at “a livestreaming platform where — I am not making this up — fans watch other people play video games.”

The reader directs our attention to “a TV network where — I am not making this up — fans watch other people play sports. ESPN is a pretty valuable property.”

The 5: Well, not as valuable as it once was — much to Disney’s consternation — but that’s a story for another time.

We’re not sure that watching a skilled gamer is quite the same thing as watching Aaron Rodgers or LeBron James or Serena Williams do their thing.

Maybe a skilled chess player? Hmmm…

Best regards,

David Gonigam

Dave Gonigam
The 5 Min. Forecast

P.S. We’re less than 24 hours away from what could be a world-changing announcement.

“A group of scientists will take the stage at a prestigious medical conference,” says Ray Blanco, “and announce to the world the potential end of disease as we know it.”

Imagine how this breakthrough could enhance the quality of your life. Imagine the wealth possibilities if you’re positioned the right way before the announcement.

It all goes down tomorrow at 7:30 a.m. EDT. Ray explains everything that’s at stake when you click here.

Dave Gonigam

Dave Gonigam

Dave Gonigam has been managing editor of The 5 Min. Forecast since September 2010. Before joining the research and writing team at Agora Financial in 2007, he worked for 20 years as an Emmy award-winning television news producer.

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